1. 研究领域
1) 微环境与病毒(KSHV/EBV/HPV等)共诱发细胞癌变机理及其干预策略;
2)微环境响应溶瘤病毒构建及其在不同恶性瘤种的应用;
3)病毒急性和慢性感染宿主关键限制性因子的发现。
2. 近年来科研成果(论文、专利、获奖等)
论文(*通讯作者)
1) Mo X, Du S, Chen X, Wang Y, Liu X, Zhang C, Zhu C, Ding L, Li Y, Tong Y, Ju Q, Qu D, Tan F*, Wei F*, Cai Q*. Lactate induces production of the tRNAHis half to promote B-lymphoblastic cell proliferation. Molecular Therapy, 2020 Nov 4;28(11):2442-2457
2) Wang Y, Du S, Zhu C, Wang C, Yu N, Lin Z, Gan J, Guo Y, Huang X, He Y, Robertson E, Qu D, Wei F, Cai Q*. Stub1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency. PLoS Pathogens, 2020 Mar 16;16(3):e1008447.
3) Ding L, Zhu Q, Zhou F, Tan H, Xu W, Pan C, Zhu C, Wang Y, Zhang H, Fu W, Qian Z, Xu H*, Wei F*, Cai Q*. Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma. PLoS Pathogens, 2019, 15(12):e1008174
4) Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S*, Wei F*, Cai Q*, Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication. Cell Death Disease. 2019, May 21;10(6):392. doi: 10.1038/s41419-019-1624-z
5) Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q*. Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis. Cell Reports. 2019, March 26, 26(13):3657-3671.
6) Gu F, Wang C, Wei F, Wang Y, Zhu Q, Ding L, Xu W, Zhu C, Cai C, Qian Z, Yuan Z, Robertson E, Cai Q*. STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus. PLoS Pathogens. 2018 Dec 10; 14(12):e1007416
7) Du S, Liu X, Cai Q*. Viral-Mediated mRNA Degradation for Pathogenesis. Biomedicines. 2018, Nov 29; 6(4). pii: E111
8) Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q*. Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth. Journal of Virology, 2018, Feb 14. doi: 10.1128/JVI.00033-18.
9) Wang C, Zhu C, Wei F, Gao S, Zhang L, Li Y, Feng Y, Tong Y, Xu J, Wang B, Yuan Z, Cai Q*. Nuclear translocation and cleavage of STAT6 is induced by Kaposi’s sarcoma-associated herpesvirus for viral latency. PLoS Pathogens, 2017, 13(1):e1006124.
10) Liu YQ, Zhang GL, Mo XH, Wang B, Wu F, Chen J, Luo H, Zhu LD, Xu MY, Zhou Q, Cai Q*, Wang XL*. A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient. J Eur Acad Dermatol Venereol, 2017, May 18. doi: 10.1111/jdv.14344
11) Wei F, Gan J, Wang C, Zhu C, Cai Q* (2016). Cell-cycle regulatory functions of the KSHV oncoproteins LANA. Frontier in Microbiology, 2016, 7(334): doi 103389
专利:
1) 蔡启良*; 陈小亭; 莫小辉; 都树娟; 朱彩霞; 王玉燕; 肿瘤乳酸微环境相关非编码小RNA分子及其应用, 2019-12-10, 中国, 201911256806.6.
2) 蔡启良*; 顾峰; 王冲; 朱彩霞; 王玉燕; 一种人疱疹病毒裂解复制激活的宿主标志物, 2018-10-16, 中国, ZL2018112044691.
3) 蔡启良*; 丁玲; 朱青; 王玉燕; 一种基于SIM靶点抗KSHV/EBV相关肿瘤小分子化合物筛选方法和应用, 2018-10-26, 中国, ZL2018112722454.
4) 蔡启良*; 朱青; 丁玲; 朱彩霞; 一种可用于恶性肿瘤分级和预后的新型标志物,2018-10-17, 中国, ZL2018112099730.
5) 蔡启良*; 朱彩霞; 蔡山山; 抗卡波氏肉瘤疱疹病毒的疫苗药物靶点SIM, 2018-1-19, 中国, 20131043187.0.
6) 蔡启良*; 干劲; 朱彩霞; 一种蛋白体外SUMO化修饰快速检测试剂盒, 2017-1-9,中国, 201710014909.6.
7) 蔡启良*; 干劲; 朱彩霞; 一种蛋白体外泛素化修饰快速检测试剂盒, 2017-1-9,中国, 201710015023.3.
8) 蔡启良*; 丁玲; 朱青; 朱彩霞; 人疱疹病毒各亚型快速检测与定量试剂和试剂盒, 2017-3-1, 中国, CN201710118846.9.
3. 近年来科研项目
1)国家自然科学基金面上项目,81971930,AURK激酶在卡波氏肉瘤病毒致瘤中作用及其机制,2020/01-2023/12,在研,主持
2)国家自然科学基金面上项目,81672015,IL-4/13-STAT6信号通路影响卡波氏肉瘤病毒感染与致病的分子机制,2017/01-2020/12,在研,主持
3)国家重点研发计划生物安全专项课题,2016YFC1200405,重要新发突发病毒宿主适应与损伤机制研究,2016/07-2018/12,211万元,已结题,主持
4)国家自然科学基金面上项目,81471930,缺氧信号介导卡波氏肉瘤病毒致病作用及机制研究,2015/01-2018/12,已结题,主持
5)国家重大基础研究“973”项目课题,2012CB519001,重要病毒持续性感染形成和维持的分子机制研究,2014/01-2016/12,已结题,主持