研究方向
病毒感染严重危害人类健康。体液免疫在病毒感染的控制、清除和监视中起关键作用。本课题组以病毒感染免疫为主要研究方向，聚焦体液免疫，综合利用免疫学、病毒学、生物信息学等研究手段，利用小鼠模型和临床标本，围绕基础和临床重大科学问题开展工作。
我们一方面以基础科学前沿为导向，利用模式抗原和模式病毒模型，阐明滤泡辅助性CD4+ T (Tfh)细胞、B细胞的分化及相互作用机制；同时瞄准临床重大科学问题，阐明乙肝病毒急慢性感染中乙肝表面抗原(HBsAg)血清学转换与体液免疫缺陷机理，以及新冠病毒与体液免疫系统的互作机制。
希望一方面能发现和解析病毒急慢性感染中体液免疫应答、维持与缺陷的总规律和机制，另外一方面能为感染的控制、疫苗的研发提供依据。
实验室论文
1. Liu Y, Wang H, Zhang J, Yang J, Bai L, Zheng B, Zheng T, Wang Y, Li J*, Zhang W*. SERINC5 Inhibits the Secretion of Complete and Genome-Free Hepatitis B Virions Through Interfering With the Glycosylation of the HBV Envelope. Front Microbiol. 2020 Apr 30;11:697. (*Coresponding author)
2. Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, Shen F, Shi B, Liu J, Peng L, Li J*, Yuan Z*. Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity. Journal of Virology. 2018 Oct 3. pii: JVI.01578-18. (*Coresponding author)
3. Li, J., E. Lu, T. Yi, and Cyster JG. EBI2 augments Tfh cell fate by promoting interaction with IL2-quenching dendritic cells. Nature. 2016; 533:110-4. (highlighted in Nature Immunology, commented in Immunol Cell Biol, recommended by Faculty of 1000)
4. Yi T., Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015; 43:764-75. (Commented in Immunity and recommended by Faculty of 1000)
5. Liu, Y*, Li, J*, J. Chen, Yuan, Z. Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways. Journal of Virology. 2015; 89: 2287-300. (*shared 1st author).
6. Li, J., K. Liu, Y. Liu, Y. Xu, F. Zhang, H. Yang, J. Liu, T. Pan, J. Chen, M. Wu, X. Zhou, and Z. Yuan. Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity. Nature Immunology. 2013; 14: 793-803. (highlighted in Nature Immunology, Nature Reviews Immunology and Natureasia, recommended by Faculty of 1000)
7. Hu, Y*., S. Lu*, Z. Song*, W. Wang*, P. Hao*, J. Li*, X. Zhang*, H. L. Yen, M. Peiris, and Z. Yuan. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet. 2013; 381:2273-9. (*shared 1st author). (highlighted and commented by Lancet.)
8. Li, J., Y. Liu, Z. Kun, K. Liu, J. Liu, H. Ding, and Z. Yuan. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. Journal of Virology. 2011; 85:6319-33.
9. Li, J., S. Lin, Q. Chen, L. Peng, J. Zhai, Y. Liu, and Z. Yuan. Inhibition of hepatitis B virus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of pre-S/S RNAs. Journal of Virology. 2010; 84:6387-99.
主要基金与人才计划：
2010-2012：复旦大学上海医学院研究学者计划
2012-2015：国家自然科学基金青年基金
2013-2014：上海市青年科技启明星计划
2015-2018：国家自然科学基金面上项目
2017-2020：国家自然科学基金面上项目
2017-2019：国家重点研发计划子课题骨干
2017-2019：复旦大学上海医学院尚医计划
2018-2020：上海市高校特聘教授(东方学者)项目
2018-2020：国家自然科学基金优秀青年基金
2018-2020：“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项
2018-2020：“长江学者奖励计划”青年项目
2019-2022：国家自然科学基金面上项目
2020-2022：复旦大学”卓越2025”人才计划