1. 研究领域
(1)主要从事分子免疫生物学,致力于探索B淋巴细胞中抗体生成的分子调控机制,尤其关注到G1早期这个时间窗口。探索AID蛋白在G1早期这一短暂时间窗口中诱导抗体基因突变,从而导致类别转换重组(class switch recombination)和体细胞高频突变(somatic hypermutation)的分子机制。
(2)研究针对不同病原体或疫苗的人体抗体免疫应答反应。主要通过招募志愿者、分离血液中单个B细胞、从单个B细胞中克隆全天然人源抗体的技术手段,来研究针对乙肝病毒(hepatitis B virus,HBV)、新冠病毒(SARS-CoV-2)以及寨卡病毒(Zika virus)等病原体的抗体应答反应;致力于筛选克隆具有较高中和效力的广谱中和抗体(broadly neutralizing antibody),并探索利用单克隆抗体预防及治疗传染性疾病的临床新策略。
2. 近年来科研成果(论文、专利、获奖等)
#共同第一作者,*通讯作者
2020年
Wang Q#*, Michailidis E#, Yu Y, Wang Z, Hurley AM, Oren DA, Mayer CT, Gazumyan A, Liu Z, Zhou Y, Schoofs T, Yao K, Nieke JP, Wu J, Jiang Q, Zou C, Kabbani M, Quirk C, Oliveira T, Chhosphel K, Zhang Q, Schneider WM, Jahan C, Ying T, Horowitz J, Caskey M, Jankovic M, Robbiani DF, Wen Y, de Jong YP*, Rice CM, Nussenzweig MC (2020). A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations. Cell Host Microbe 28(2):335-349.
Van Rompay KKA*, Coffey LL, Kapoor T, Gazumyan A, Keesler RI, Jurado A, Peace A, Agudelo M, Watanabe J, Usachenko J, Singapuri A, Immareddy A, Ardeshir A, Stuart JB, Bournazos S, Ravetch JV, Balderes PJ, Lorenz IC, Esswein SR, Keeffe J, Bjorkman PJ, Wang Q, Rice CM, MacDonald MR, Nussenzweig MC*, Robbiani DF* (2020). A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques. Proc Natl Acad Sci U S A 117(14):7981-7989.
2019年
Robbiani DF#*, Olsen PC#, Costa F#, Wang Q#, Oliveira TY#, Nery N Jr, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA Jr, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R Jr, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M Jr, Rajagopal L, Adams Waldorf KM, Dudley DM, Simmons HA, Mejia A, O'Connor DH, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA#, Ko AI#, Nussenzweig MC#* (2019). Risk of Zika microcephaly correlates with features of maternal antibodies. J Exp Med 216(10):2302-2315.
2018年
Keeffe JR#, Van Rompay KKA#, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC*, Robbiani DF* (2018). A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates. Cell Rep 25(6):1385-1394.
Delgado-Benito V#, Rosen DB#, Wang Q, Gazumyan A, Pai JA, Oliveira TY, Sundaravinayagam D, Zhang W, Andreani M, Keller L, Kieffer-Kwon KR, Pękowska A, Jung S, Driesner M, Subbotin RI, Casellas R, Chait BT, Nussenzweig MC, Di Virgilio M* (2018). The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell 72(4):636-649.
2017年
Wang Q#*, Kieffer-Kwon KR#, Oliveira TY, Mayer CT, Yao K, Pai J, Cao Z, Dose M, Casellas R, Jankovic M, Nussenzweig MC*, Robbiani DF* (2017). The cell cycle restricts activation-induced cytidine deaminase activity to early G1. J Exp Med 214, 49-58.
Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A, Medina-Ramirez M, Sanders RW, Nussenzweig MC* (2017). The microanatomic segregation of selection by apoptosis in the germinal center. Science 2017 358, 6360-6367.
2016年
von Boehmer L*, Liu C, Ackerman S, Gitlin AD, Wang Q, Gazumyan A, Nussenzweig MC (2016). Sequencing and cloning of antigen-specific antibodies from mouse memory B cells. Nat Protoc 11, 1908-1923.
2015年
Wang Q#, Shen B#, Chen L#, Zheng P#, Feng H, Hao Q, Liu X, Liu L, Xu S, Chen J*, Teng J* (2015). Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Oncogene 34, 1006-1018.
Robbiani DF*, Deroubaix S, Feldhahn N, Oliveira TY, Callen E, Wang Q, Jankovic M, Silva IT, Rommel PC, Bosque D, Eisenreich T, Nussenzweig A, Nussenzweig MC* (2015). Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. Cell 162, 727-737.
Zheng P, Wang Q, Teng J, Chen J* (2015). Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology. Pharmacol Res 99, 11-15.
2014年
Qian J#, Wang Q#, Dose M#*, Pruett N#, Kieffer-Kwon KR#, Resch W, Liang G, Tang Z, Mathé E, Benner C, Dubois W, Nelson S, Vian L, Oliveira TY, Jankovic M, Hakim O, Gazumyan A, Pavri R, Awasthi P, Song B, Liu G, Chen L, Zhu S, Feigenbaum L, Staudt L, Murre C, Ruan Y, Robbiani DF, Pan-Hammarström Q, Nussenzweig MC, Casellas R* (2014). B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell 159, 1524-1537.
Wang Q, Oliveira T, Jankovic M, Silva IT, Hakim O, Yao K, Gazumyan A, Mayer CT, Pavri R, Casellas R, Nussenzweig MC*, Robbiani DF* (2014). Epigenetic targeting of activation-induced cytidine deaminase. Proc Natl Acad Sci U S A 111, 18667-18672.
Meng FL#, Du Z#, Federation A#, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE*, Liu XS, Alt FW* (2014). Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell 159, 1538-1548.
2013年及以前
Wang Q#, Shen B#, Zheng P#, Feng H, Guo Y, Cao W, Chen L, Liu X, Zhao G, Xu S, Shen W, Chen J*, Teng J* (2013). BmCREC is an endoplasmic reticulum (ER) resident protein and required for ER/Golgi morphology. J Biol Chem 288, 26649-26657.
Feng H#, Chen L#, Wang Q#, Shen B, Liu L, Zheng P, Xu S, Liu X, Chen J, Teng J* (2013). Calumenin-15 facilitates filopodia formation by promoting TGF-beta superfamily cytokine GDF-15 transcription. Cell Death Dis 4, e870.
Wang Q#, Feng H#, Zheng P#, Shen B, Chen L, Liu L, Liu X, Hao Q, Wang S, Chen J, Teng J* (2012b). The intracellular transport and secretion of calumenin-1/2 in living cells. PLoS One 7, e35344.
Wang Q#, Chen L#, Chen L#, Shen B, Liu Y, Chen J, Teng J* (2012). The tau-like protein in silkworm (Bombyx mori) induces microtubule bundle formation. Front Biosci (Elite Ed) 4, 998-1008.
Wang Q#, Shen B#, Zheng P#, Feng H, Chen L, Zhang J, Zhang C, Zhang G, Teng J*, Chen J* (2010a). Silkworm coatomers and their role in tube expansion of posterior silkgland. PLoS One 5, e13252.
Wang Q, Teng J*, Shen B, Zhang W, Guo Y, Su X, Zhang C, Yu AC, Chen J* (2010b). Characterization of kinesin-like proteins in silkworm posterior silk gland cells. Cell Res 20, 713-727.
Gong JC, Gou XP, Xu Y, Tang L, Wang Q, Wang ZT, Chen F* (2004) Construction and transient expression of chimeric genes consisting of the promoter of rice RSSG8 gene and GUS gene in tobacco. Journal of Sichuan University (Natural Science Edition) 41: 1070-75;
3. 在研科研项目
2017
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入选上海高校特聘教授“东方学者”
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2018
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入选国家高层次海外青年人才引进项目
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2019-2022
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国家自然科学基金,面上项目,31872730
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研究AID蛋白在B细胞G1早期时间窗口中
诱导抗体多样性的 调控机制
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2021-2024
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国家自然科学基金,面上项目,32070947
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不同免疫史人群对乙肝表面抗原HBsAg的
抗体免疫应答机制及其应用研究
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