1. 研究领域：
课题组主要研究方向为新型抗肿瘤抗感染药物研究。针对临床疾病诊治需求，开发新型溶瘤病毒、抗肿瘤、抗感染药物递送系统，为恶性肿瘤和感染性疾病的治疗提供新技术和新方法。
2. 近年来科研成果（论文、专利、获奖等）
1) Xihui Gao#, Sha Li#, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*. Virus‐mimicking nucleic acid nanogel reprograms the microglia and macrophage for glioblastoma therapy. Adv. Mater., 2020, Accepted.
2) Xihui Gao*, #, Junqiang Ding#, Qianqian Long#, Changyou Zhan*. Virus-mimetic systems for cancer diagnosis and therapy. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2020, Accepted.
3) Fei Ding, Xihui Gao, Xiangang Huang, Huan Ge, Miao Xie, Jiwen Qian, Jie Song, Yuehua Li*, Xinyuan Zhu, Chuan Zhang*. Polydopamine-coated nucleic acid nanogel for siRNA-Mediated low-temperature photothermal therapy. Biomaterials. 2020, 245, 119976.
4) Sha Li#, Jinliang Xu#, Jun Qian, Xihui Gao*. Engineering extracellular vesicles for cancer diagnosis and therapy: recent advances and challenges in clinical translation. Biomater. Sci., 2020, doi: 10.1039/D0BM01385D.
5) Cong Wang#, Wanbing Sun#, Jun Zhang#, Jianping Zhang, Qinghua Guo, Xingyu Zhou, Dandan Fan, Haoran Liu, Ming Qi, Xihui Gao, Haiyan Xu, Zhaobing Gao, Mei Tian, Hong Zhang, Jianhong Wang, Zixuan Wei, Nicholas J Long, Ying Mao, Cong Li. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nature Biomedical Engineering, 2020, doi: 10.1038/s41551-020-00618-4.
6) Sha Li, Yijing Wu, Fei Ding, Jiapei Yang, Jing Li, Xihui Gao*, Chuan Zhang*, Jing Feng*. Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer. Nanoscale, 2020, 12, 10854-10862.
7) Xihui Gao#, Sha Li#, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, Rapid detection of exosomal microRNAs using virus-mimicking fusogenic vesicles. Angew. Chem. Int. Ed. Engl. 2019, 58, 8719-8723.
8) Quanbing Mou, Yuan Ma, Fei Ding, Xihui Gao, Deyue Yan, Xinyuan Zhu, Chuan Zhang*. two-in-one chemogene assembled from drug-integrated antisense oligonucleotides to reverse chemoresistance. J. Am. Chem. Soc. 2019, 141, 17, 6955–6966.
9) Xihui Gao#, Qi Yue#, Zining Liu, Mengjing Ke, Xingyu Zhou, Sihan Li, Jianping Zhang, Ren Zhang, Ying Mao and Cong Li*, Guiding brain tumor surgery via blood brain barrier permeable gold nanoprobes with acid triggered MRI/SERRS signal. Adv. Mater., 2017, 29, 1603917.
10) Xihui Gao, Jun Qian, Shuyan Zheng, Yinzhi Changyi, Jianping Zhang, Shenghong Ju*, Jianhua Zhu, Cong Li*, Overcoming the blood–brain barrier for delivering drugs into the brain by using adenosine receptor nanoagonist. ACS Nano 2014, 8, 3678-3689.
11) Han Xue, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xihui Gao*, Jing Feng, Xinyuan Zhu and Chuan Zhang*. DNA tetrahedron-based nanogels for siRNA delivery and gene silencing. Chem. Commun., 2019, 55, 4222-4225.
12) Xihui Gao#，Qi Yue#，Yikang Liu，Dandan Fan，Kun Fan，Sihan Li，Jun Qian，Limei Han，Fang Fang, Fulin Xu, Daoying Geng, Liang Chen*, Xin Zhou, Ying Mao, and Cong Li*, Image-guided chemotherapy with specifically tuned blood brain barrier permeability in glioma margins. Theranostics 2018, 8, 3126.
13) Huihui Yan*, #, Xihui Gao#, Yunfei Zhang, Wenju Chang, Jianhui Li, Xinwei Li, Qin Du*, Cong Li*, Imaging tiny hepatic tumor xenografts via endoglin-targeted paramagnetic/optical nanoprobe. ACS Appl. Mater. Interfaces, 2018, 10, 17047-17057.
14) Xihui Gao, Cong Li*, Nanoprobes visualizing gliomas by crossing the blood brain tumor barrier. Small, 2014, 10, 426-440.
15) Qi Yue#, Xihui Gao#, Yang Yu, Yang Li, Wei Hua, Kun Fan, Ren Zhang, Jun Qian, Liang Chen*, Cong Li* and Ying Mao*. An EGFRvIII targeted MRI/SERRS dual-modal gold nanoprobe guiding brain tumor surgery. Nanoscale, 2017, 9, 7930-7940.
16) Xihui Gao#, Yuancheng Wang#, Yikang Liu, Qi Yue, Zining Liu, Mengjing Ke, Shengyuan Zhao, Cong Li*, Nanoagonist-mediated endothelial tight junction opening: A strategy for safely increasing brain drug delivery in mice. J. Cereb. Blood Flow Metab. 2017, 37, 1410-1424.
17) Xihui Gao#, Jun Qian#, Shuyan Zheng, Ying Xiong, Jiahao Man, Binxin Cao, Lu Wang, Shenghong Ju*, Cong Li*, Up-regulating blood brain barrier permeability of nanoparticles via multivalent effect. Pharm. Res., 2013, 30, 2538-2548.
3. 近年来科研项目
1) 国家自然科学基金面上项目，2021/1-2024/12，在研，主持；
2) 上海市青年科技启明星计划（A类），2020/05-2023/04，在研，主持；
3) 国家自然科学基金青年项目，2018/01-2021/12，在研，主持；
4) 中国博士后创新人才支持计划，2017/07-2019/07，已结题，主持；
5) 中国博士后科学基金面上项目，2017.07-2019.07，已结题，主持；
6) 上海市博士后日常工作项目，2017/07-2019/07，已结题，主持；