研究领域: 功能性治愈慢性乙肝病毒感染的基础研究
主要研究方向:
(1) 乙肝表面抗原(HBsAg)的组装、降解和释放
(2) 乙肝病毒共价闭合环状DNA(cccDNA)形成和转录调控
(3) 乙肝病毒聚合酶的功能研究
代表性论文(第一/通讯作者):
1) Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion. Gut. 2024, 73: 668-681. Commentary by Eberhard Hildt and Jianming Hu: Gut. 2024, 73: 566-567.
2) A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments. Nature Communications. 2022, 13: 4614. (Featured article)
3) IFN-inducible MX2 is a host restriction factor of hepatitis B virus replication. Journal of Hepatology. 2020, 72: 865-876.
4) An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion. Antiviral Research. 2019, 162: 118-129.
5) Lost Small Envelope Protein Expression from Naturally Occurring PreS1 Deletion Mutants of Hepatitis B Virus Is Often Accompanied by Increased HBx and Core Protein Expression as Well as Genome Replication. Journal of Virology. 2021, 95(14): e0066021.
6) Carbonyl J acid derivatives block protein-priming of hepadnaviral P protein and DNA-dependent DNA synthesis activity of hepadnaviral nucleocapsids. Journal of Virology. 2012, 86: 10079-92.
7) Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptase. Journal of Virology. 2012, 86: 6394-407.
授权专利:
Sequence of reverse transcriptase gene and method of use (授权USPTO patent No. 8,748,087) Inventor: Yu-Mei Wen, Yong-Xiang Wang, Zhang-Mei Ma.
获奖:
教育部高等学校科学研究优秀成果奖自然科学奖(二等奖):乙肝病毒毒株的新生物学特性与意义(第一完成人);复旦大学十佳教师团队(钟扬式科研团队)奖:乙型肝炎慢性化机制及对策研究团队;复旦大学基础医学院杰出贡献奖;第四届感染病与肝病卓越研究年度论坛卓越论文奖(华夏肝脏病学联盟和上海仁心公益基金会)。
在研科研项目:
近5年主持3项国家自然科学基金面上项目;作为核心项目骨干参与4项国家级和省部级项目。
教书育人:
参与《医学微生物学》等3门本科生课程讲授;近5年指导2名复旦大学基础医学专业本科生完成毕业论文;指导1名英国帝国理工学院本科生完成课程实习;独立指导6名硕士生;协助指导2名博士生;独立指导的硕士生中,1人获得国家奖学金一等奖,硕士学位论文工作发表在Gut、Nature Communications和Antiviral Research等经典权威期刊。