1. 研究领域
(1) 肿瘤微环境响应型智能纳米载药系统的设计、制备及细胞内转运
(2) 核酸类、多肽类抗病毒药物的设计、筛选与递送
(3) 核酸适配体在肠道感染性疾病诊治中的应用
2. 近5年来发表文章
(1) Bin Lei, Miaoxin Chen, Yizhou Wang, Junqi Zhang*, Shouhong Xu*, Honglai Liu. Double Security Drug Delivery System DDS Constructed by Multi-Responsive (pH/redox/US) Colloids Surf B Biointerfaces. (2020), https://doi.org/10.1016/j.colsurfb.2020.111022.
(2) Yinxing Shen, Mengya Li, Tianqi Liu, Jing Liu, Youhua Xie, Junqi Zhang*, Shouhong Xu*, Honglai Liu. A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells. Int J Nanomedicine 2019:14 4029–4044
(3) Yinxing shen†, Junqi Zhang†, Weiju Hao, Tong Wang, Jing liu, Youhua Xie, Shouhong Xu, honglai liu. Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells, Int J Nanomedicine 2018, 537–553.
(4) Weiju Hao, Tong Wang, Danyang Liu, Yazhuo Shang, Junqi Zhang*, Shouhong Xu*, Honglai Liu Folate-conjugated pH-controllable fluorescent nanomicelles acting as tumor targetable drug carriers. Microchimica Acta(2017), 2881–2891.
(5) Weiju Hao, Yinxing Shen, Danyang Liu, Yazhuo Shang, Junqi Zhang*, Shouhong Xu*, Honglai Liu. Dual-pH-sensitivity and tumour targeting core–shell particles for intracellular drug delivery. RSC Advances(2017),851-860.
(6) Weiju Hao, Danyang Liu, Yazhuo Shang, Junqi Zhang*, Shouhong Xu*, Honglai Liu. pH-Triggered copolymer micelles as drug nanocarriers for intracellular delivery. RSC Advances(2016), 29149–29158.
(7) Xiaoli Ye, Ming Zhou, Yonggang He, Yanmin Wan, Weiya Bai, Shuai Tao, Yanqin Ren, Xinxin Zhang, Jianqing Xu, Jing Liu, Junqi Zhang*, Kanghong Hu*, Youhua Xie*. Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide. Sci Rep.(2016), doi: 10.1038/srep29391.
(8) Liang Yan, Su Qu, Gang Liu, Lei Liu, Yao Yu, Guohui Ding, Yanfeng Zhao, Yixue Li, Youhua Xie*, Junqi Zhang*, Di Qu*. Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection. PLoS One(2016), DOI:10.1371/journal.pone.0149702.
(9) Danyang Liu, Junqi Zhang*, Shouhong Xu* and Honglai Liu. Membrane property and biofunction of phospholiposome incorporated with anomeric galactolipids,Springerplus(2016), doi: 10.1186/s40064-016-2236-z.
3. 在研科研项目
(1) 国家科技重大专项子课题: 抗诺如病毒新方法
(2) 国家自然科学基金:智能大分子在生物膜环境中的响应行为及其对膜功能的调控机制
(3) 国家自然科学基金:合成糖脂在磷脂单分子、双分子层膜中的界面行为研究——DNA载体的设计和制备
在研经费总计118.71万元。