获得奖项:
1.“十一五”国家科技计划执行优秀团队奖
2.2015年上海市专利发明金奖
3.科学中国人(2015)年度奖
4.2018年上海市专利发明金奖
研究方向:
1.新型治疗性疫苗及耐受性疫苗研究
2.新型疫苗佐剂的研究
3.临床免疫学检测及新型标志物研究
4.免疫耐受机制及病毒宿主免疫调控机理研究
科研项目:
2022年上海市市级科技重大专项“重大突发传染病防控关键核心技术研究”,上海市市级科技重大专项资助的课题。方向召集人
2022年
复旦疫苗研究与转化校企联合实验室项目,“新型过敏性哮喘治疗性疫苗研发”,课题负责人
2021年国家自然科学基金委项目,“创新佐剂系统提升新冠疫苗广谱免疫效果的研究”,课题负责人
2021年国家自然科学基金委项目,“靶向免疫代谢屏障及免疫负反馈回路的佐剂研究”,课题负责人
2020年国家重点研发计划(十三五)项目,“新冠DNA疫苗(INO-4800)研发(参与)”,参与人
2020年国家重点研发计划项目,“非洲猪瘟病毒感染、致病与免疫分子机制研究(参与)”, 参与人
2020年复旦疫苗研究与转化校企联合实验室项目,“自身抗原个性化肿瘤免疫治疗技术的评价”, 课题负责人
课程讲授:
本科生课程:老年基础医学进展
研究生课程:病原微生物与宿主细胞的相互作用
学术兼职(不超过5项):
·
美国《Human Vaccines and Immunotherapeutics》杂志副主编
·
国际DNA 疫苗学会理事会理事
·
中国微生物学会理事
·
国际疫苗学会会员
·
中国疫苗行业协会核酸疫苗分会 主任委员
代表性论著(不超过10篇/部, *通讯作者):
1. Sheng Jiang,
Shuting Wu, Gan Zhao, Yue He, Xinrong Guo, Zhiyu Zhang, JiawangHou, Yuan Ding,
Alex Cheng &Bin Wang*. Identification
of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein,
Emerging Microbes & Infections,2022. DOI:
10.1080/22221751.2022.2043727.
2. Sheng Jiang,
Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang
Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami
Patella, David B. Weiner, Kate Broderick &Bin Wang*. Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2
with Optimized Sequence on The Induction of Protective Responses Against
SARS-Cov-2 Challenge in Mouse Model. Hum Vaccin Immunother. 2021, 21;1-11.
doi: 10.1080/21645515.2021.2016201.
3. Dan
Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, and Bin Wang*. Development
of A Therapeutic Vaccine Targeting Merkel Cell Polyomavirus Capsid Protein VP1 against Merkel cell carcinoma. NPJ Vaccines (2021)6:119.
4. Xiaoyu
Zhou, Shushu Zhao, Yue He, ShuangGeng, Yan Shi*, and Bin Wang*. Precise spatio-temporal interruption of regulatory T
cell-mediated CD8+ T cell suppression leads to tumor immunity. Cancer Research
2019,79:585-597.
5. Feifei
Yang, Xueping Yu, Chenliang Zhou, Richeng Mao, Mengqi Zhu, Haoxiang Zhu,
Zhenxuan Ma, BidishaMitra, Gan Zhao, Yuxian Huang, Haitao Guo*, Bin Wang*,
Jiming Zhang*. Hepatitis B e antigen induces the expansion of monocytic
myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis
B virus infection. PLoSPathog 2019, 15 (4): e1007690.
6. Shijie
Zhang, Shushu Zhao, Xiang Jin, Bin Wang*
and Gan Zhao*. Microneedles Improve The Immunogenicity Of DNA Vaccines. Human
Gene Therapy 2018, 29:1004-1010.
7. Wencong
Yu, ShuangGeng, Yuanzhen Suo, Xunbin Wei, Qiliang Cai, Bing Wu, Xian Zhou, Yan
Shi* and Bin Wang*. Critical role of
regulatory T cells in the latency and stress-induced reactivation of HSV-1. Cell Reports 2018. 25:2379–2389.
8. Weidong
Zhao, Gan Zhao, and Bin Wang*. Revisiting GM-CSF as an adjuvant
for therapeutic vaccines. Cellular
and Molecular Immunology. 2017, doi:10.1038/cmi.2017.105
9. Xian Zhou,
ShuangGeng, Shijie Zhang, Weidong Zhao, Yumei Wen, Xuanyi Wang* and Bin Wang*. Biomarkers Distinguish HBeAg Seroconverted from
Non-Converted Individuals in Chronic Hepatitis B Patients Treated with a
Therapeutic Vaccine. Cytokine 2017, doi.org/10.1016/j.cyto.2017.11.004.
10. ShuangGeng,
Yiwei Zhong, Xiaoyu Zhou, Gan Zhao, Xiaoping Xie, Yechun Pei, Hu Liu, Huiyuan
Zhang, Yan Shi* &Bin Wang*. Induced regulatory T cells superimpose
their suppressive capacity with effector T cells in lymph nodes via
antigen-specific S1p1-dependent egress blockage. Frontiers in Immunology, 2017,
8:663.
代表性专利(不超过5项):
1. 针对一种防治老年痴呆症复合疫苗及其制备方法 (申请号:CN201110217429.2)
2. 针对一种呼吸道合胞体病毒疫苗及其制备方法与应用 (申请号:201510082407.8)
3. 针对一种治疗和/或预防I型糖尿病的组合物及其应用 (申请号:201611203605.6)
4. 针对氢氧化铝在制备治疗肝癌药物中的应用 (申请号:CN201310084217.0)
5. 针对抗呼吸道合胞病毒的全人广谱中和抗体4F1及其应用 (申请号201910143346X)