获得人才项目:
2015,国家留学基金委,公派访问学者
获得奖项:
2021,复旦大学五四青年奖章集体(主要负责人)
2020, 复旦大学抗击新冠肺炎疫情先进个人
研究方向:
方向一 冠状病毒抗宿主先天免疫调控及致病机制研究
方向二 EBV潜伏感染及致瘤机制研究
科研项目:
1. 2021, 教育部科技创新工作专项,病毒反向遗传技术体系的研究,参与
2. 2020,国家自然科学基金新型冠状病毒专项研究,新型冠状病毒辅助蛋白的功能及与宿主互作机制研究,参与
3. 2020,上海市科委,新型冠状病毒感染嗜性、复制和传播力的研究,参与
4. 2020,国家自然科学基金面上项目,AURK激酶在卡波氏肉瘤病毒致瘤中作用及其机制,参与
5. 2020,国家自然科学基金面上项目,PKCα对冠状病毒感染的神经细胞退行性病变的调控,参与
6. 2012,国家自然科学基金青年项目,α属冠状病毒S蛋白受体识别和细胞嗜性相关功能区的研究,主持
7. 2009,教育部博士点新教师基金,1群冠状病毒S基因上的重组对细胞嗜性的影响,主持
课程讲授:
本科生课程:医学微生物学B,基于疾病的多学科教学(PBL),医学生综合素养,病原生物与人类,Animal diseases
and human health (MBBS)
研究生课程:动物疾病与人类健康
代表性论著:
1. Yunqing Gu #, Jun Cao # , Xinyu Zhang #,
Hai Gao # , Yuyan Wang #, Jia Wang # , Juan He #, Xiaoyi Jiang #, Jinlan
Zhang, Guanghui Shen, Jie Yang, Xichen Zheng, Gaowei Hu, Yuanfei Zhu, Shujuan
Du , Yunkai Zhu, Rong Zhang, Jianqing Xu, Fei Lan, Di Qu, Guoliang Xu, Yun Zhao*,
Dong Gao*, Youhua Xie*, Min Luo* and Zhigang Lu*. Receptome profiling
identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Res. 2022 Jan;32(1):24-37.
2. Yinghui Liu#, Gaowei Hu#, Yuyan Wang#,
Wenlin Ren#, Xiaomin Zhao#, Fansen Ji, Yunkai Zhu, Fei Feng, Mingli Gong,
Xiaohui Ju, Yuanfei Zhu, Xia Cai, Jun Lan, Jianying Guo, Min Xie, Lin Dong,
Zihui Zhu, Jie Na, Jianping Wu, Xun Lan, Youhua Xie, Xinquan Wang, Zhenghong
Yuan, Rong Zhang* and Qiang Ding*. Functional and genetic analysis of viral
receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2,
Proc Natl Acad Sci USA. 2021 Mar 23; 118(12): e2025373118.
3. Yunkai Zhu#, Fei Feng#, Gaowei Hu#, Yuyan
Wang#, Yin Yu, Yuanfei Zhu, Wei Xu, Xia Cai, Zhiping Sun, Wendong Han, Rong
Ye, Hongjun Chen, Qiang Ding, Di Qu, Youhua Xie, Qiliang Cai*, Zhenghong Yuan*,
Rong Zhang*. A genome-wide CRISPR screen identifies host factors that regulate
SARS-CoV-2 entry, Nature Communications, 2021, 12(1): 961
4. 张荣#,易志刚#,王玉燕#,滕峥#,徐巍,宋武慧,蔡霞,孙志平,谷陈建,周艳秋,陈洪友,叶荣,韩文东,朱云凯,冯飞,房方皓,李崇山,张曦,瞿涤,付晨*,谢幼华*,袁正宏*,新型冠状病毒上海株(nCoV-SH01)的分离和鉴定,微生物与感染,2020,15(1):111-121.
5. Yuyan Wang#, Shujuan Du#, Caixia Zhu#, Chong Wang#, Nuoya Yu, Ziqi
Lin, Jin Gan, Yi Guo, Xinxin Huang, Yuping He, Erle Robertson, Di Qu, Fang Wei,
Qiliang Cai*, STUB1 Is Targeted by the SUMO-Interacting Motif of EBNA1 to
Maintain Epstein-Barr Virus Latency, PLoS Pathogens, 2020, 16(3):e1008447.
6. Xiaohui Mo#, Shujuan Du#, Xiaoting Chen#, Yuyan Wang#, Xiaoqing Liu#, Chongqi Zhang, Caixia Zhu, Ling Ding, Ying
Li, Yin Tong, Qiang Ju, Di Qu, Fei Tan*, Fang Wei*, Qiliang Cai*. Lactate
Induces Production of the tRNA(His) Half to Promote B-lymphoblastic Cell
Proliferation, Molecular Therapy, 2020, 28(11): 2442-2457
7. Feng Gu#, Chong Wang#, Fang Wei#, Yuyan
Wang#, Qing Zhu, Ling Ding, Wenjia Xu, Caixia Zhu, Cankun Cai, Zhikang
Qian, Zhenghong Yuan, Erle Robertson, Qiliang Cai*, STAT6 degradation and
ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus.
PLoS Pathogens, 2018, 14(12):e1007416.
8. Yize Li#, Shuvojit Banerjee#, Yuyan
Wang#, Stephen A. Goldstein, Beihua Dong, Christina Gaughan, Robert H.
Silverman*, and Susan R. Weiss*. Activation of RNase L is dependent on OAS3
expression during infection with diverse human viruses. PNAS, 2016,
113(8):2241-2246.
代表性专利:
1. 蔡启良,都树娟,瞿涤,朱彩霞,王玉燕,刘子睿,一种感染与非感染恶性肿瘤诊治的新型靶标及其干预应用 (202011448488.6)
2. 蔡启良,陈小亭, 莫小辉, 都树娟,朱彩霞, 王玉燕,肿瘤乳酸微环境相关非编码小RNA分子及其应用 (ZL201911256806.6)
3. 蔡启良,丁玲,朱青,王玉燕,一种基于SIM靶点抗KSHV/EBV相关肿瘤小分子化合物筛选方法和应用 (ZL2018112722454)
4. 蔡启良,顾峰,王冲,朱彩霞,王玉燕,一种人疱疹病毒裂解复制激活的宿主标志物 ( ZL2018112044691)