夏帅青年研究员

职  务:

电  话:18317070995

邮  箱:sxia15@fudan.edu.cn

研究方向:人冠状病毒感染机制的研究

个人简介

教育经历及工作经历

教育经历:

2008.09—2013.09  蚌埠医学院医学检验专业本科生

2013.09—2018.07  复旦大学病原生物学博士研究生


工作经历:

2018.07—2021.1   复旦大学基础医学院博士后

2021.02—至今    复旦大学基础医学院青年研究员

科研领域及成果

获得人才项目:

2021,上海市人才发展资金资助


获得奖项:

2019,复旦大学优秀博士后;

2020,“一健康基金”新冠肺炎疫情防控特别奖,优秀教师三等奖;

2021,第六届中国科协优秀科技论文奖。


研究方向:

1. 人冠状病毒感染机制的研究

2. 广谱抗人冠状病毒入侵抑制剂的研究


科研项目:

1. 国家自然科学基金委员会, 青年项目, 82002142, 高效广谱抗冠状病毒新型拟肽类抑制剂的功能及抗病毒机制的研究, 2020-01至2021-12, 16万元, 在研, 主持;

2. 国家科技部,重大专项项目,SQ2018ZX100301, 防治重大呼吸道病毒感染疾病的原创生物技术产品研发及战略储备, 2018-01至2020-12, 4080万元, 结题, 课题骨干;

3. 复旦大学引进人才项目、中国博士后基金等


代表性论著(不超过5/部):

1.     Xia, Shuai#; Chan, Jasper Fuk-Woo#; Wang, Lijue#; Jiao, Fanke; Kenn Ka-Heng Chik; Chu, Hin; Lan, Qiaoshuai; Xu, Wei; Wang, Qian; Wang, Chao; Yuen, Kwok-Yung; Lu, Lu; Jiang, Shibo; Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant. Cell Research. 2022. 1-3.

2.     Xia, Shuai#; Liu, Meiqin#; Wang, Chao#; Xu, Wei#; Lan, Qiaoshuai; Feng, Siliang; Qi, Feifei; Bao, Linlin; Du, Lanying; Liu, Shuwen; Qin, Chuan; Sun, Fei; Shi, Zhengli; Zhu, Yun*; Jiang, Shibo*; Lu, Lu*; Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Research, 2020, 30(4): 343-355.

3.     Xia Shuai#, Lan Qiaoshuai#, Zhu Yun#, Wang Chao#, Xu Wei#, Li Yutang, Wang Lijue, Jiao Fanke, Zhou Jie, Hua Chen, Wang Qian, Cai Xia, Wu Yang, Gao Jie, Liu Huan, Sun Ge, Jan Münch, Frank Kirchhoff, Yuan Zhenghong*, Xie Youhua*, Sun Fei*, Jiang Shibo*, Lu Lu* Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation. Signal Transduction and Targeted Therapy (2021), 6(1):288.

4.     Xia, Shuai#; Lan, Qiaoshuai#; Su, Shan#; Wang, Xinling#; Xu, Wei; Liu, Zezhong; Zhu, Yun; Wang, Qian*; Lu, Lu*; Jiang, Shibo* The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin. Signal Transduction and Targeted Therapy (2020) 5:92

5.     Xia, Shuai#; Yan, Lei#; Xu, Wei#; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien Te K; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, IanA*; Jiang, Shibo*; Yang, Bei*; Lu, Lu*; A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike, Science Advances, 2019, 5(4): 0-eaav4580.


代表性专利(不超过5项)

1.    广谱地抑制人类冠状病毒感染的多肽及其应用 (已授权:CN201610070216.4)

2.    多肽、其制备方法和用途(申请号:CN202180001804.1)

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