研究方向：
1. 乙型肝炎病毒（HBV）分子生物学、分子病毒学、免疫学；HBV动物模型及治疗药物研发；重组HBV载体系统及其应用；
2. 病毒生物信息学；远古病毒与新发/新现病毒研究；
3. 肝脏基因表达调控；肝癌及其它肿瘤发生发展机制及药物研究。
科研项目：
2019，国家自然科学基金面上项目，“基于白介素21的细胞治疗促进乙型肝炎病毒持续性感染清除的机制及应用研究”，主持
2017，国家重点研发计划，“重要疫源动物微生物群落与未新病原的致病耐药性和适应进化研究”，子课题负责人
2017，国家自然科学基金面上项目，“决定肝细胞对乙型肝炎病毒易感性的关键分子研究”，主持
2012，国家自然科学基金面上项目，“Prox1蛋白抑制乙型肝炎病毒的分子机制及应用研究”，主持
课程讲授：
本科生课程：
医学微生物学，Medical
Microbiology
研究生课程：
医学分子病毒学（一），医学分子病毒学进展
代表性论著：
1. Shen, Z.#*, Wu, J.#, Gao, Z. #, Zhang, S., Chen, J., He, J., Guo, Y.,Deng, Q., Xie, Y.*, Liu, J. #*, Zhang, J.* (2022). High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein. Nucleic Acids Res. 2022;50(4):2157–2171
2. Shen, Z.#, Wu, J.#, Gao, Z.#, Wang, J.,Zhu, H., Mao, R., Wang, X., Zhang, J.*, Xie, Y.*, Liu, J*. Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection.Theranostics 2020; 10(12): 5600-5612
3. Gu, C.#, Ming, L.#, Fang, Y., Liu, X.,Zhang, J., Zelinskyy, G., Deng, Q., Liu,J*., Xie, Y*. Restriction of exogenous DNA expression by SAMHD1. Sci Bull 2020; 65(7):573-586
4. Shen, Z.#, Liu, J.#*, Wu, J.#, Zhu, Y., Li, G., Wang, J., Luo, M., Deng, Q.,Zhang, J.*, Xie, Y*. IL-21-based therapies induce clearance of hepatitis B virus persistence in mouse models. Theranostics 2019; 9(13): 3798-3811.
5. Shen, Z.#, Yang, H.#, Yang, S.#, Wang,W., Cui, X., Zhou, X., Liu, W., Pan, S., Liu, Y., Zhang, J., Zhang, J.*, Xie Y.*, Liu, J*. Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance.Nat Commun 2017; 8: 2119.
6. Liu, Y., Zhang, Y., Wang, S., Dong, Q.Z., Shen, Z., Wang, W., Tao, S., Gu, C., Liu,J.*, Xie, Y.*, Qin, L. X*. Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating IL-8 expression.
Hepatology 2017; 66(6):1894-1909
7. Han, Y.#, Gu, L.#, Liu, J.#, Li, X.#, Wang, M., Gong, Q., Yu, D., Yang, Z., Zhang, D.,Yang, H., Shen, Z., Zhu, H., Xie, Y.*, Zhang, X*. Association of Mutations in Toll-like Receptor 2 Signaling Genes With Fulminant Form of Hepatitis B-Related Acute Liver Failure. J Infect Dis 2017;215(8):1221-1230.
8. Bai, W.#, Cui, X.#, Chen, R., Tao, S.,Hong, R., Zhang, J., Zhang, J., Wang, Y., Xie, Y.*, Liu, J.*. Re-Designed Recombinant Hepatitis B Virus Vectors Enable Efficient Delivery of Versatile Cargo Genes to epatocytes with Improved Safety. Viruses 2016;8(5) doi: 10.3390/v8050129
9. Liu, Y., Ye, X., Zhang, J.B., Ouyang, H.,Shen, Z., Wu, Y., Wang, W., Wu, J., Tao, S., Yang, X., Qiao, K., Zhang, J., Liu, J.*, Fu, Q.*, Xie, Y*. PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing beta-catenin expression and nuclear translocation. Oncogene 2015;34(44):5524-5535
10. Zhao, X., Wu, Y., Duan, J., Ma, Y., Shen, Z., Wei, L., Cui, X.,Zhang, J., Xie, Y.*, Liu, J*.
Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS. J Proteome Res 2014;13(12):5391-5402
代表性专利：
1. 一种人乙型肝炎病毒重组载体及其应用 (已授权：ZL2015 1
0132238.4）
2. 一种乙型肝炎病毒感染的小鼠模型的构建方法（已授权：ZL2014 1 0425641.1）
3. 一种人乙型肝炎病毒X蛋白的单克隆抗体及用途（已授权：ZL2015 1
0133236.7）
4. 一种抑制人乙型肝炎病毒感染的短肽及其应用（已授权：ZL 2011 1
0122517.4）
5. 一种高效复制的人乙型肝炎病毒重组载体及其应用（已授权：ZL 2011 1
0039085.0）